BIG Breast International Group
We will find a cure for breast cancer through global research and collaboration.

Translational Research

BIG trials and research programmes always incorporate translational research within them. Translational research provides the link between the discoveries in the laboratory (basic science research) and their application for the benefit of patients (clinical research). It functions as a bridge between these two worlds and is based on two principles often referred to as “bench to bedside” and “bedside to bench”.


Biological samples - Translational research is conducted using biological samples (such as tumour tissue or blood) collected in the context of BIG trials from patients who have consented to their use, either for specific projects, or for yet undefined future research. The biological samples collected are maintained in qualified biorepositories, which in general are independent from the partners involved in running a particular clinical trial.  At a specific point in time, these samples – as well as clinical and other data collected during the course of a trial – are made available to scientists from around the world, both from within and outside of the BIG network.  

Research project proposals - All translational research project proposals are carefully reviewed and prioritized by qualified experts and are approved by the steering committees of the respective trials. This process ensures the best use of precious biological materials and gives the best hope for rapid discoveries that can lead to better treatments for individual patients.


BIG trials anticipate the future, collecting biospecimens for translational research to help us identify the treatments most suited to each individual patient


Tissue handling - It is essential that biomaterials collected for translational research purposes are of the highest quality. To this end, BIG, with support of the Breast Cancer Research Foundation (BCRF) / University of Michigan, prepared a video and support materials translated into multiple languages that cover the basics of appropriate tumour tissue sampling, preservation, packaging and labelling. 

 

>>> How to best collect and handle biosamples?

 

Biomaterial inventory - The BIG Biomaterials Inventory was created with support from the Breast Cancer Research Foundation (BCRF) / University of Michigan and aims to provide a detailed summary of which materials have been collected for translational research purposes in the context of BIG clinical trials. The inventory therefore serves as a resource for researchers who may wish to access such samples. Details about the relevant contact information and procedures are indicated for each trial.

>>> BIG Biomaterial Inventory

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