BIG Breast International Group

BIG-NABCG


BIG and the North American Breast Cancer Group (NABCG) – a network of major US and Canadian-based research groups supported by the US National Cancer Institute (NCI) – have been meeting annually and in topic-specific working groups since 2005.

 



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BIG-NABCG Annual meeting 2014, Brussels, Belgium

 

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BIG-NABCG Annual meeting 2014, Brussels, Belgium


Together they identify difficult aspects of breast cancer research, focus on research areas not supported by the pharmaceutical industry, and collaborate to resolve common problems.

Their current focus is metastatic breast cancer. In particular, experts working under the BIG-NABCG umbrella tackle the following issues: development of innovative clinical trial designs in the genomics era, data-sharing in the context of molecular screening programmes and analysis of circulating biomarkers (circulating tumour cells, and circulating tumour DNA).

This collaboration is supported by the generous help of the Breast Cancer Research Foundation.

For more information about the NABCG visit: http://www.upci.upmc.edu/NABCG/index.cfm


Together, BIG and NABCG strive to improve the care and cure rates of patients with breast cancer through international collaboration.



Joint BIG-NABCG publications

  • “An International Ki67 Reproducibility Study” in JNCI (2013) by Polley MC, Leung SCY, McShane LM, Gao D, Hugh JC, Mastropasqua MG, Viale G, Zabaglo LA, Penault-Llorca F, Bartlett JMS, Gown AM, Symmans WF, Piper T, Mehl E, Enos RA, Hayes DF, Dowsett M, Nielsen TO.

     

  • "Pregnancy after breast cancer: if you wish, ma'am." in Breast Cancer Res Treat (2011) by Pagani O, Partridge A, Korde L, Badve S, Bartlett J, Albain K, Gelber R, Goldhirsch A; Breast International Group; North American Breast Cancer Group Endocrine Working Group.

  • "Assessment of Ki67 in Breast Cancer: Recommendations from the International Ki67 in Breast Cancer Working Group in JNCI (2011) by Dowsett M, Nielsen TO, A’Hern R, Bartlett J, Coombes RC, Cuzick J, Ellis M, Henry NL, Hugh JC, Lively T, McShane L, Paik S, Penault-Llorca F, Prudkin L, Regan M, Salter J, Sotiriou C, Smith IE, Viale G, Zujewski JA, Hayes DF.

    • "Proposals for uniform collection of biospecimens from neoadjuvant breast cancer clinical trials: timing and specimen types" in the Lancet Oncology (2011) by Loi S, Symmans WF, Bartlett J, Fumagalli D, Van't Veer L, Forbes JF, et al.

    • "Recommendations for collection and handling of specimens from group breast cancer clinical trials, from onsite collection through shipping to the central bank" in JCO (2008) by Leyland‐Jones BR, Ambrosone CB, Bartlett JMS, Ellis MJC, Enos RA, Raji A, Pins MR, Zujewski JA, Hewitt SM, Forbes JF, Abramovitz M, Braga S, Cardoso F, Harbeck N, Denkert C, Jewell SD.

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